The vitamin D receptor (VDR) is a trans-acting transcriptional regulatory factor. It can be expressed in the intestines, kidneys, skin, skeletal tissue, and a variety of immune cells. VDRs have been thought of as a potential mechanism by which vitamin D influences calcium absorption inside the gut, cell division, and bone skin maintenance.
In the nucleus, the VDR is usually phosphorylated on serine residues by a number of protein kinases. When ligand binding takes place, the molecule triggers multiple intracellular signaling pathways which can be independent of the concentrate on gene transcribing process.
The vitamin D receptor is a member of the superfamily of trans-acting transcriptional regulatory factors. It includes a zinc finger DNA-binding domain, a ligand-binding domain name, and a transcriptional service customer-x-pectations.com site. These elements will be required for the protein’s functional activity.
The cDNA related to the calciferol receptor was isolated via a human digestive tract cDNA selection. RNA blot hybridization from the cDNA explained a single RNA species of about 4. six kb.
VDR expression is found in different cell types which includes epithelial skin cells, glial fibrillary acidic healthy proteins, dendritic cellular material, platelets, neutrophils, macrophages, and oligodendrocytes. Studies using confocal microscopy have demonstrated VDR nuclear staining in many different cellular civilizations.
Some studies have explored the effects of VDR variants on osteoporosis and BMD. Yet , these studies have been limited in their sample size and have been inconclusive.
Meta-analyses of innate association research have also revealed heterogeneity. This may be a result of hidden stratification of the populations learned.